The Pocotaligo Massacre triggers the start of the Yamasee War in colonial South Carolina.

The Yamasee War was a conflict fought in South Carolina from 1715 to 1717 between British settlers from the Province of Carolina and the Yamasee, who were supported by a number of allied Native American peoples, including the Muscogee, Cherokee, Catawba, Apalachee, Apalachicola, Yuchi, Savannah River Shawnee, Congaree, Waxhaw, Pee Dee, Cape Fear, Cheraw, and others. Some of the Native American groups played a minor role, while others launched attacks throughout South Carolina in an attempt to destroy the colony.