The Battle of Cerignola is fought. It is noted as one of the first European battles in history won by small arms fire using gunpowder.

The Battle of Cerignola was fought on 28 April 1503 between Spanish and French armies outside the town of Cerignola, Apulia, Kingdom of Naples, approximately 80 kilometres (50 mi) west of Bari. The Spanish force under the command of Gonzalo Fernández de Córdoba comprising around 9,000 men, including 2,000 Landsknecht pikemen, 1,000 arquebusiers and 20 cannons, defeated the French force of 9,000 men, mainly gendarme heavy cavalry and Swiss mercenary pikemen, with about 40 cannons, led by Louis d'Armagnac, Duke of Nemours, who was killed during the battle.