World War I: The use of poison gas in World War I escalates when chlorine gas is released as a chemical weapon in the Second Battle of Ypres.

World War I, or the First World War, also known as the Great War, was a global conflict between two coalitions: the Allies and the Central Powers. Major areas of conflict included Europe and the Middle East, as well as parts of Africa and the Asia-Pacific. The war saw important developments in weaponry including tanks, aircraft, artillery, machine guns, and chemical weapons. One of the deadliest conflicts in history, it resulted in an estimated 15 to 22 million military and civilian casualties and genocide. The movement of large numbers of people was a major factor in the deadly Spanish flu pandemic.